Cassava Sciences is an American pharmaceutical company based in Austin, Texas. The company was founded in 1998 by Remi Barbier as Pain Therapeutics, Inc., changing its name in 2019. Cassava was developing simufilam, an oral-tablet drug candidate for the treatment of Alzheimer's disease. Development for simufilam was discontinued in November 2024 after failing to show clinical benefit in phase III clinical trials. In June 2024, the United States Department of Justice charged an advisor to Cassava Sciences, Hoau-Yan Wang, with fraud over research results related to the experimental drug. Less than a month later, the president, chief executive officer and chairman of the board, Remi Barbier, resigned along with Lindsay Burns, his wife, who was a Cassava senior vice president and Wang's co-author. The U.S. Securities and Exchange Commission filed charges in September 2024 against Cassava, Barbier, Burns and Wang with allegations including violations of "antifraud provisions of the federal securities laws" and "reporting provisions of the federal securities laws". Wikipedia